{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335072/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335072"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"LINEMAP: Quantitative temporal reconstruction of single-cell lineage topology and division history from evolving CRISPR barcodes","description":"This study generated CRISPR barcode sequencing data from a PyMT-Cas9 mammary tumor cell line engineered with integrated homing guide RNA (hgRNA) lineage barcodes. Cells were collected at day 5 and day 14 following doxycycline-induced Cas9 activation to characterize barcode mutation accumulation and lineage evolution. These data were used to evaluate LINEMAP, a computational framework for quantitative reconstruction of lineage topology and cell division history from evolving CRISPR barcodes.","dates":{"publication":"2026/06/15"},"accession":"GSE335072","cross_references":{"GSM":["GSM9805526","GSM9805527"],"GPL":["16417"],"GSE":["335072"],"taxon":["Mus musculus"]}}