{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335098/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335098"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Tyrphostin-AG4178 on ex-vivo mouse ovarian follicles in eIVFG ovulation system","description":"Ovulation is a coordinated, multicellular process carried out in the antral follicle involving gonadotropin-stimulus, cumulos-oocyte complex expansion, follicle rupture, followed by luteinization. Ovulation can be prevented by targeted inhibition of upstream signalling molecules via tool compounds such as Tyrphostin-AG4178, which binds to EGFR and thus prevents downstream MEK/ERK, prostaglandin, and Pgr signaling. We exposed ex vivo mouse ovarian follicles grown in an encapsulated in-vitro follicle growth (eIVFG) system to Tyrphostin-AG4178 after stimulus with hCG and performed bulk-RNA sequencing on whole follicles to observe the transcriptomic response to targeted ovulation inhibition.","dates":{"publication":"2026/06/23"},"accession":"GSE335098","cross_references":{"GSM":["GSM9805786","GSM9805775","GSM9805776","GSM9805777","GSM9805778","GSM9805779","GSM9805780","GSM9805781","GSM9805770","GSM9805771","GSM9805782","GSM9805783","GSM9805772","GSM9805784","GSM9805773","GSM9805774","GSM9805785"],"GPL":["30172"],"GSE":["335098"],"taxon":["Mus musculus"]}}