GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335098/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335098GEOGSEfalseEffect of Tyrphostin-AG4178 on ex-vivo mouse ovarian follicles in eIVFG ovulation systemOvulation is a coordinated, multicellular process carried out in the antral follicle involving gonadotropin-stimulus, cumulos-oocyte complex expansion, follicle rupture, followed by luteinization. Ovulation can be prevented by targeted inhibition of upstream signalling molecules via tool compounds such as Tyrphostin-AG4178, which binds to EGFR and thus prevents downstream MEK/ERK, prostaglandin, and Pgr signaling. We exposed ex vivo mouse ovarian follicles grown in an encapsulated in-vitro follicle growth (eIVFG) system to Tyrphostin-AG4178 after stimulus with hCG and performed bulk-RNA sequencing on whole follicles to observe the transcriptomic response to targeted ovulation inhibition.2026/06/23GSE335098GSM9805786GSM9805775GSM9805776GSM9805777GSM9805778GSM9805779GSM9805780GSM9805781GSM9805770GSM9805771GSM9805782GSM9805783GSM9805772GSM9805784GSM9805773GSM9805774GSM980578530172335098Mus musculus