GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335141/primaryOK200Methylation profilingHomo sapiensMethylation profiling by genome tiling arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335141GEOGSEfalseGenome-wide DNA Methylation Profiling in Postpartum Depression: A Longitudinal Whole-Blood StudyThis dataset contains genome-wide DNA methylation data derived from whole human blood samples collected from postpartum women enrolled in a longitudinal cohort study (2018–2023, N = 827). Blood samples were drawn within 6 days of delivery (t0) and at 12 weeks postpartum (t4). Participants were assessed longitudinally for postnatal depression (EPDS), perceived stress (PSS-10), and mother-infant attachment (MPAS). A subset of N = 247 participants with complete blood sampling was used for methylation analysis; mothers with the most severe depressive symptoms (PPD group, n = 17, DSM-5 confirmed) were compared to a euthymic healthy control group (HC, n = 24). Genome-wide methylation profiling was performed using the Illumina Infinium Human MethylationEPICv2 BeadChip. Differential methylation analysis was conducted using the ChAMP package (BMIQ normalization, limma-based DMP calling). The goal of this study is to identify epigenetic signatures associated with postpartum depression.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 sapiens