{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335235/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335235"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure","description":"RNA sequencing was performed to investigate the role of fast skeletal myosin binding protein-C (fMyBP-C) in cardiac pathology and heart failure. fMyBP-C, a paralog of cardiac myosin binding protein-C (cMyBP-C), is upregulated in diseased mouse hearts. To determine its functional consequences, we generated a Mybpc3_Exon 33 deletion model, which alters the structure of the C10 domain of cMyBP-C. Transcriptomic profiling was used to characterize gene expression changes including fMyBP-C associated with loss of cMyBP-C, providing insight into the molecular mechanisms by which fMyBP-C contributes to cardiac dysfunction.","dates":{"publication":"2026/09/30"},"accession":"GSE335235","cross_references":{"GSM":["GSM9808794","GSM9808795","GSM9808793","GSM9808798","GSM9808796","GSM9808797"],"GPL":["23479"],"GSE":["335235"],"taxon":["Mus musculus"],"PMID":["[42554829]"]}}