GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335235/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335235GEOGSEfalseFast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failureRNA sequencing was performed to investigate the role of fast skeletal myosin binding protein-C (fMyBP-C) in cardiac pathology and heart failure. fMyBP-C, a paralog of cardiac myosin binding protein-C (cMyBP-C), is upregulated in diseased mouse hearts. To determine its functional consequences, we generated a Mybpc3_Exon 33 deletion model, which alters the structure of the C10 domain of cMyBP-C. Transcriptomic profiling was used to characterize gene expression changes including fMyBP-C associated with loss of cMyBP-C, providing insight into the molecular mechanisms by which fMyBP-C contributes to cardiac dysfunction.2026/09/30GSE335235GSM9808794GSM9808795GSM9808793GSM9808798GSM9808796GSM980879723479335235Mus musculus[42554829]