{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335248/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335248"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of U251 cells following tRF-3021a knockdown at 8 and 48 hours","description":"tRNA-derived fragments (tRFs) are relatively recently discovered small RNAs implicated in gene-regulatory processes in diverse biological contexts, but there have been few reports of clear phenotypic roles for these small RNAs in cancer progression. High expression of the 3' tRFs tRF-3009a, tRF-3021a, and tRF-3030a is associated with poor overall survival in low-grade glioma. In glioblastoma cells, these tRFs enhance invasion and migration, while tRF-3021a is uniquely required for cell proliferation, suppression of apoptosis, and maintenance of global protein synthesis. This RNA-seq study profiles transcriptomic changes following tRF-3021a knockdown in U251 cells at early and late time points (8 hours and 48 hours)","dates":{"publication":"2026/09/25"},"accession":"GSE335248","cross_references":{"GSM":["GSM9809003","GSM9809004","GSM9809001","GSM9809002","GSM9808996","GSM9808997","GSM9808994","GSM9809005","GSM9808995","GSM9808998","GSM9808999","GSM9809000"],"GPL":["34284","34281"],"GSE":["335248"],"taxon":["Homo sapiens"]}}