GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335354/primaryOK200TranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335354GEOGSEfalseJejunal gene expression in surfactant protein D (Sftpd) knockout and wild-type mice after doxorubicin-induced intestinal toxicitySurfactant protein D (SP-D, gene Sftpd) is an anti-inflammatory host defence collectin produced by epithelial cells on mucosal surfaces. We investigated whether SP-D attenuates chemotherapy-induced gastrointestinal toxicity and inflammation in mice. Sftpd-/- (KO) mice and Sftpd+/+ (WT) littermates received a single intraperitoneal injection of doxorubicin (20 mg/kg) or isotonic saline and were sacrificed on day 3 or day 7. Genome-wide expression in the jejunum was profiled on the Affymetrix GeneChip Mouse Transcriptome Array 1.0.2026/06/24GSE335354GSM9812440GSM9812446GSM9812424GSM9812445GSM9812423GSM9812426GSM9812425GSM9812442GSM9812420GSM9812441GSM9812444GSM9812422GSM9812421GSM9812443GSM9812409GSM9812428GSM9812427GSM9812408GSM9812429GSM9812407GSM9812435GSM9812413GSM9812412GSM9812434GSM9812415GSM9812437GSM9812436GSM9812414GSM9812431GSM9812430GSM9812433GSM9812411GSM9812432GSM9812410GSM9812439GSM9812417GSM9812438GSM9812416GSM9812419GSM981241820775335354Mus musculus