GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335460/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335460GEOGSEfalseDifferentially expressed genes (DEGs) in HEK-293T cells treated with the culture supernatant of yeast-form Candida albicansThe yeast-form of Candida albicansis known to secrete bioactive metabolites that modulate host cellular responses. In this study, we investigated the transcriptional impact of yeast-form C. albicansculture supernatant on human embryonic kidney (HEK)-293T cells. HEK-293T cells were treated with the supernatant, followed by RNA sequencing (RNA-seq) to identify differentially expressed genes (DEGs). Transcriptomic profiling revealed a distinct gene expression signature in treated cells compared to controls. Functional enrichment analysis of these DEGs highlighted significant modulation of pathways associated with cellular stress responses and signal transduction. These findings provide a comprehensive genomic landscape of the host cell response to soluble factors derived from the yeast-form C. albicans, offering insights into the molecular mechanisms underlying fungus-host cell interactions at the transcriptional level.2026/06/20GSE335460GSM9814090GSM9814091GSM9814089GSM9814087GSM9814088GSM981408616791335460Homo sapiens