{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335461/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335461"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Differentially expressed genes (DEGs) in the corneas of Muc13 KO mice versus wild-type controls","description":"The mucosal barrier protein MUC13 plays a critical role in maintaining epithelial homeostasis, yet its function remains poorly defined. In this study, we utilized a combination of genetic knockout models and transcriptomic profiling to elucidate the impact of MUC13 deficiency on tissue responses. Comparative analysis of corneal tissues from 6-week-old male Muc13-knockout (C57BL/6 background) and wild-type (WT) male mice revealed profound transcriptional perturbations in Muc13-/- mouse cornea. RNA sequencing identified a distinct repertoire of differentially expressed genes (DEGs) associated with the loss of MUC13. These findings demonstrate that MUC13 is a pivotal modulator of the epithelial barrier.","dates":{"publication":"2026/06/20"},"accession":"GSE335461","cross_references":{"GSM":["GSM9814092","GSM9814093","GSM9814096","GSM9814097","GSM9814094","GSM9814095"],"GPL":["17021"],"GSE":["335461"],"taxon":["Mus musculus"]}}