GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335461/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335461GEOGSEfalseDifferentially expressed genes (DEGs) in the corneas of Muc13 KO mice versus wild-type controlsThe mucosal barrier protein MUC13 plays a critical role in maintaining epithelial homeostasis, yet its function remains poorly defined. In this study, we utilized a combination of genetic knockout models and transcriptomic profiling to elucidate the impact of MUC13 deficiency on tissue responses. Comparative analysis of corneal tissues from 6-week-old male Muc13-knockout (C57BL/6 background) and wild-type (WT) male mice revealed profound transcriptional perturbations in Muc13-/- mouse cornea. RNA sequencing identified a distinct repertoire of differentially expressed genes (DEGs) associated with the loss of MUC13. These findings demonstrate that MUC13 is a pivotal modulator of the epithelial barrier.2026/06/20GSE335461GSM9814092GSM9814093GSM9814096GSM9814097GSM9814094GSM981409517021335461Mus musculus