{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335471/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335471"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age [RNA-seq]","description":"The numerical abundance of diverse naive CD8 T cell clones is essential to provide broad protection against infection and cancer. Here, we uncover a sex-biased mechanism of immune aging in which an early, male-biased depletion of naive CD8 T cells driven by accelerated, antigen-agnostic differentiation into virtual memory cells is combined with age-related thymic involution that limits naive CD8 T cell replenishment. These mechanisms lead to contraction of lymph nodes and reduced local naive T cell clone availability, limiting antigen recognition capacity. Therapeutic thymus regeneration via androgen ablation repopulates naive CD8 T cells in lymph nodes, which reinvigorates tumor-specific T cell responses and enhances responsiveness to immune checkpoint blockade. These findings reveal the crucial impact of sex and age on naive T cell clone abundance in lymph nodes and suggest strategies to restore immune competence in middle age males.","dates":{"publication":"2026/08/20"},"accession":"GSE335471","cross_references":{"GSM":["GSM9814280","GSM9814265","GSM9814287","GSM9814288","GSM9814266","GSM9814285","GSM9814263","GSM9814286","GSM9814264","GSM9814283","GSM9814261","GSM9814262","GSM9814284","GSM9814281","GSM9814282","GSM9814260","GSM9814302","GSM9814269","GSM9814300","GSM9814289","GSM9814267","GSM9814268","GSM9814301","GSM9814290","GSM9814291","GSM9814276","GSM9814298","GSM9814299","GSM9814255","GSM9814277","GSM9814274","GSM9814296","GSM9814297","GSM9814275","GSM9814294","GSM9814272","GSM9814273","GSM9814295","GSM9814292","GSM9814270","GSM9814271","GSM9814293","GSM9814258","GSM9814259","GSM9814256","GSM9814278","GSM9814279","GSM9814257"],"GPL":["34290"],"GSE":["335471"],"taxon":["Mus musculus"]}}