GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335490/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335490GEOGSEfalseSingle-cell transcriptomic profiling of 4-NQO-induced oral squamous cell carcinoma in a mouse modelTo investigate the cellular heterogeneity and molecular drivers of oral squamous cell carcinoma (OSCC), we performed single-cell RNA sequencing (scRNA-seq) on tongue tissues from a 4-nitroquinoline 1-oxide (4-NQO)-induced mouse model. This dataset revealed eight distinct cell populations, with a significant reduction in epithelial cells and an increase in fibroblasts in OSCC compared to controls. Notably, a distinct Col1a1⁺ epithelial subpopulation was identified that exhibited the highest epithelial-mesenchymal transition (EMT) signature and was significantly expanded in OSCC. This study provides a valuable resource for understanding the transcriptional landscape and cellular dynamics underlying OSCC progression.2026/06/16GSE335490GSM9814526GSM9814527GSM9814524GSM9814525GSM9814528GSM981452924247335490Mus musculus