GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335693/primaryOK200TranscriptomicsHomoExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335693GEOGSEfalseTranscriptomic analysis of DHODH inhibition in PIK3CA-mutant colorectal cancerThis study investigates the transcriptional consequences of genetic and pharmacological DHODH inhibition in PIK3CA-mutant colorectal cancer. RNA sequencing was performed in RKO cells following either DHODH knockdown (shDHODH versus shNT) or treatment with the DHODH inhibitor HL6 (HL6 versus DMSO) to characterize the transcriptional programs regulated by DHODH and compare the effects of genetic and pharmacological inhibition.2026/06/19GSE335693GSM9817679GSM9817678GSM9817677GSM9817676GSM9817675GSM9817685GSM9817674GSM9817684GSM9817683GSM9817682GSM9817681GSM981768030128335693Homo