GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335770/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335770GEOGSEfalseARID1B loss remodels the chromatin landscape to promote sorafenib resistance in hepatocellular carcinomaCUT&RUN in HepG2 and HLF HCC cell lines mapping H3K27ac, H3K4me3, ARID1B, FOXA1, FOXA2 occupancy under sorafenib treatment and ARID1B-KO conditions. 2x2 factorial (genotype x treatment), 2 biological replicates per condition. Identifies cBAF-pioneer factor chromatin axis mediating sorafenib sensitivity. Preprint: https://doi.org/10.64898/2026.06.11.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 sapiens10.64898/2026.06.11.731725