{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335773/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335773"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pooled CRISPR/Cas9 screen identifies chromatin regulatory genes mediating sorafenib resistance in HepG2 hepatocellular carcinoma cells","description":"Focused pooled CRISPR/Cas9 screen in HepG2 HCC cells. ~6,000 sgRNAs targeting ~750 chromatin/TF genes (~800 non-targeting controls). 4 conditions: T0, DMSO, sorafenib 2.5 µM IC10, sorafenib 4 µM IC50; 3 replicates each. MAGeCK identified ARID1B among top sorafenib-resistance hits. Preprint: https://doi.org/10.64898/2026.06.11.731725","dates":{"publication":"2026/06/19"},"accession":"GSE335773","cross_references":{"GSM":["GSM9820619","GSM9820620","GSM9820621","GSM9820624","GSM9820614","GSM9820625","GSM9820622","GSM9820623","GSM9820617","GSM9820618","GSM9820615","GSM9820616"],"GPL":["18573"],"GSE":["335773"],"taxon":["Homo sapiens"],"DOI":["10.64898/2026.06.11.731725"]}}