GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335773/primaryOK200OtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335773GEOGSEfalsePooled CRISPR/Cas9 screen identifies chromatin regulatory genes mediating sorafenib resistance in HepG2 hepatocellular carcinoma cellsFocused pooled CRISPR/Cas9 screen in HepG2 HCC cells. ~6,000 sgRNAs targeting ~750 chromatin/TF genes (~800 non-targeting controls). 4 conditions: T0, DMSO, sorafenib 2.5 µM IC10, sorafenib 4 µM IC50; 3 replicates each. MAGeCK identified ARID1B among top sorafenib-resistance hits. Preprint: https://doi.org/10.64898/2026.06.11.7317252026/06/19GSE335773GSM9820619GSM9820620GSM9820621GSM9820624GSM9820614GSM9820625GSM9820622GSM9820623GSM9820617GSM9820618GSM9820615GSM982061618573335773Homo sapiens10.64898/2026.06.11.731725