GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335813/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335813GEOGSEfalseTranscriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytesHuman induced pluripotent stem cell–derived cardiomyocytes were used to investigate the cardiomyocyte-intrinsic effects of neprilysin inhibition during hypertrophic stress. Cardiomyocytes were treated with endothelin-1, the neprilysin inhibitor sacubitrilat, a combination of endothelin-1 and sacubitrilat, or vehicle control. Bulk RNA sequencing was performed to characterize transcriptional remodeling induced by endothelin-1 and to determine whether neprilysin inhibition modifies this response.2026/06/22GSE335813GSM9821574GSM9821573GSM9821572GSM9821571GSM9821578GSM9821577GSM9821576GSM9821575GSM9821579GSM9821570GSM9821581GSM982158034284335813Homo sapiens