{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336151/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mesocricetus auratus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336151"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Weissella confusa Wc1982 ameliorates hyperlipidemia through gut microbiota remodeling and hepatic PPARα/NF-κB signaling in hamsters","description":"This study investigated whether the human feces-derived candidate probiotic Weissella confusa Wc1982 ameliorates high-fat diet-induced hyperlipidemia in Golden Syrian hamsters and characterized the associated hepatic transcriptional responses. Male LVG hamsters received a normal diet, a high-fat diet, or a high-fat diet plus oral Wc1982 (5 × 10^8 CFU/day) for six weeks. Liver RNA sequencing showed that Wc1982 increased expression of genes involved in PPARα-regulated fatty acid uptake, fatty acid oxidation, and ketogenesis, while reducing expression of canonical and non-canonical NF-κB pathway genes and fibrosis-related genes. The dataset contains raw gene-level counts and FPKM-normalized expression values for 18 liver samples.","dates":{"publication":"2026/06/30"},"accession":"GSE336151","cross_references":{"GSM":["GSM9828947","GSM9828958","GSM9828959","GSM9828948","GSM9828956","GSM9828945","GSM9828957","GSM9828946","GSM9828954","GSM9828943","GSM9828944","GSM9828955","GSM9828952","GSM9828953","GSM9828949","GSM9828950","GSM9828951","GSM9828960"],"GPL":["28997"],"GSE":["336151"],"taxon":["Mesocricetus auratus"]}}