GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336151/primary200OKTranscriptomicsMesocricetus auratusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336151GEOGSEfalseWeissella confusa Wc1982 ameliorates hyperlipidemia through gut microbiota remodeling and hepatic PPARα/NF-κB signaling in hamstersThis study investigated whether the human feces-derived candidate probiotic Weissella confusa Wc1982 ameliorates high-fat diet-induced hyperlipidemia in Golden Syrian hamsters and characterized the associated hepatic transcriptional responses. Male LVG hamsters received a normal diet, a high-fat diet, or a high-fat diet plus oral Wc1982 (5 × 10^8 CFU/day) for six weeks. Liver RNA sequencing showed that Wc1982 increased expression of genes involved in PPARα-regulated fatty acid uptake, fatty acid oxidation, and ketogenesis, while reducing expression of canonical and non-canonical NF-κB pathway genes and fibrosis-related genes. The dataset contains raw gene-level counts and FPKM-normalized expression values for 18 liver samples.2026/06/30GSE336151GSM9828947GSM9828958GSM9828959GSM9828948GSM9828956GSM9828945GSM9828957GSM9828946GSM9828954GSM9828943GSM9828944GSM9828955GSM9828952GSM9828953GSM9828949GSM9828950GSM9828951GSM982896028997336151Mesocricetus auratus