GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336205/suppl/GSE336205_genes_fpkm_expression.txt.gzftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336205/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336205GEOGSEfalseDUSP5 regulates ferroptosis in pancreatic cancer by down-regulating SCD1 expression via ERK1/2This study aimed to explore the role and mechanism of DUSP5 in pancreatic ductal adenocarcinoma (PDAC). RNA sequencing was performed in DUSP5-overexpressing PANC-1 cells and control cells to identify differentially expressed genes. The results revealed that DUSP5 significantly downregulated stearoyl-CoA desaturase 1 (SCD1), a key enzyme involved in fatty acid metabolism and ferroptosis regulation. Our findings indicate that DUSP5 promotes ferroptosis and suppresses PDAC proliferation through the ERK1/2-SCD1 signaling pathway.2026/06/28GSE336205GSM9829997GSM9829998GSM9829995GSM9829996GSM9829993GSM982999424676336205Homo sapiens