{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336336/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Pseudomonas aeruginosa"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336336"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Pseudomonas aeruginosa LysR-type transcriptional regulator, PA1290, essential for productive biofilm and influences virulence and pathogenesis","description":"The transposon insertion mutation of regulator PA1290 (PA1290∷Tn) significantly reduced biofilm formation, while enhancing virulence in Drosophila melanogaster fruit fly and BALB/C mouse infection models. This regulator influenced bacterial motility, c-di-GMP signaling, and the RhlI-RhlR and Pseudomonas quinolone signal (PQS) quorum-sensing (QS) systems. We used RNA-seq assays to identify the regulatory mechanisms of PA1290. We observed that 391 genes were up-regulated and 114 genes were down-regulated in the absence of PA1290, many of which are involved in rhamnolipid synthesis, type II, type III, and type VI secretion systems, and QS systems.","dates":{"publication":"2026/06/27"},"accession":"GSE336336","cross_references":{"GSM":["GSM9832809","GSM9832810"],"GPL":["18287"],"GSE":["336336"],"taxon":["Pseudomonas aeruginosa"]}}