GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336336/primary200OKGenomicsPseudomonas aeruginosaGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336336GEOGSEfalseA Pseudomonas aeruginosa LysR-type transcriptional regulator, PA1290, essential for productive biofilm and influences virulence and pathogenesisThe transposon insertion mutation of regulator PA1290 (PA1290∷Tn) significantly reduced biofilm formation, while enhancing virulence in Drosophila melanogaster fruit fly and BALB/C mouse infection models. This regulator influenced bacterial motility, c-di-GMP signaling, and the RhlI-RhlR and Pseudomonas quinolone signal (PQS) quorum-sensing (QS) systems. We used RNA-seq assays to identify the regulatory mechanisms of PA1290. We observed that 391 genes were up-regulated and 114 genes were down-regulated in the absence of PA1290, many of which are involved in rhamnolipid synthesis, type II, type III, and type VI secretion systems, and QS systems.2026/06/27GSE336336GSM9832809GSM983281018287336336Pseudomonas aeruginosa