GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336399/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336399GEOGSEfalseCharacterization of the cancer-associated field of injury in the nasal epithelium in never-smokersLung cancer in never-smokers represents a distinct and growing clinical challenge, yet early detection strategies largely target smokers. Here, we demonstrate that nasal epithelial gene expression alterations previously associated with lung cancer in current and former smokers are conserved in never-smokers. Notably, immune-related pathways, including interferon signaling, are similarly suppressed in malignant nodules in ever and never smokers. These findings suggest shared molecular mechanisms of lung carcinogenesis in ever and never smokers and should motivate validation of airway-based biomarkers in never-smoker populations.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 sapiens[42349086]