{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336602/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Clostridioides difficile"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336602"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of curing the phi027 prophage for gene expresson in Clostridioides difficile clinical isolate 500/12","description":"Clostridioides difficile is a clinically important nosocomial pathogen whose virulence is primarily associated with toxin production and can be influenced by prophage carriage. In this study, we investigated the molecular basis of phi027-dependent phenotypic differences previously observed between the clinical RT176 strain 500/12 and its prophage-free derivative CKH08. Comparative transcriptomic analysis revealed that loss of phi027 was associated with reduced expression of the sinR/R' operon, downregulation of multiple flagellar biosynthesis genes.","dates":{"publication":"2026/07/01"},"accession":"GSE336602","cross_references":{"GSM":["GSM9838636","GSM9838637","GSM9838638","GSM9838639","GSM9838643","GSM9838640","GSM9838641","GSM9838642"],"GPL":["30071"],"GSE":["336602"],"taxon":["Clostridioides difficile"]}}