GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336629/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336629GEOGSEfalseIntegrated Transcriptomic Profiling of Rectal and Adipose HIV-1 Reservoirs Relative to Matched PBMCs in ART-Treated IndividualsHIV-1 persistence in anatomical reservoirs remains a major obstacle to a functional cure under suppressive antiretroviral therapy. This study used bulk RNA-seq to characterize host transcriptomic features across matched peripheral blood mononuclear cells (PBMCs), rectal tissue, and subcutaneous adipose tissue (SAT) from ART-treated people with HIV. Transcriptomic profiling revealed tissue-specific remodeling in rectal and adipose reservoirs relative to matched PBMCs, including extracellular matrix remodeling, immunometabolic alterations, and shared PI3K-Akt-related transcriptional features.2026/06/25GSE336629GSM9839002GSM9838991GSM9838992GSM9838993GSM9838994GSM9839000GSM9838990GSM9839001GSM9838999GSM9838989GSM9838995GSM9838996GSM9838997GSM983899829480336629Homo sapiens