{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336756/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336756"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Compartmentalisation of m6A (N6-methyladenosine) methylated RNA in somatic or axonal subcellular locations is dependent on Nerve Growth Factor (NGF) state in sympathetic neurons [Axon-meRIP-seq]","description":"Sympathetic neurons were culture in compartmentalised chambers in medium with NGF (control condition). Cells were then subjected to NGF starvation for 18 hours followed by 1 hour of restimulation. RNA was collected from either cell bodies (CB) or axons (Ax) from these neurons for meRIP-seq. Here, we find a strong compartmentalisation effect, in which RNA is hypermethylated in axons in both control and restimulated conditions. We also find that a select few RNA species are hypermethylated in restimulated axons compared to control axons, suggesting a fast time-dependent function for m6A marks in these RNAs.","dates":{"publication":"2026/07/01"},"accession":"GSE336756","cross_references":{"GSM":["GSM9841817","GSM9841816","GSM9841804","GSM9841803","GSM9841802","GSM9841801","GSM9841800","GSM9841789","GSM9841788","GSM9841787","GSM9841786","GSM9841809","GSM9841808","GSM9841807","GSM9841806","GSM9841805","GSM9841815","GSM9841814","GSM9841813","GSM9841812","GSM9841811","GSM9841799","GSM9841810","GSM9841798","GSM9841797","GSM9841796","GSM9841795","GSM9841794","GSM9841793","GSM9841792","GSM9841791","GSM9841790"],"GPL":["30172"],"GSE":["336756"],"taxon":["Mus musculus"]}}