{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336811/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336811"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Ly6Chi and Ly6Clow blood monocytes from naïve and Heligmosomoides polygyrus bakeri infected mice","description":"Alterations to monocyte output and function occur during infections that drive classical Th1-type inflammation. The degree to which the circulating monocyte compartment responds to infections that initiate alternative types of response is poorly understood. Here we describe a unique state of the monocyte compartment associated with type 2-favouring intestinal helminths. The adapted monocyte state in a type 2 setting was associated with an interferon-signature. Acquisition of this interferon-induced state provided helminth-infected animals with unappreciated systemic protection against secondary bacterial infection, but still allowed for the development of effective type-2 immunity. This pathway of monocyte education was completely distinct from that described in Th1-settings and involved an endogenous-bacteria-mediated induction of type I IFN that led to adaptive lymphocyte-dependent IFN- priming of monocytes. These findings reveal an IFN-driven mechanism of monocytes education that enables the host to be simultaneously protected against type-2 infections at barrier sites and type-1 infections in the circulation.","dates":{"publication":"2026/06/29"},"accession":"GSE336811","cross_references":{"GSM":["GSM9843057","GSM9843058","GSM9843059","GSM9843060","GSM9843061","GSM9843062","GSM9843063","GSM9843064"],"GPL":["17021"],"GSE":["336811"],"taxon":["Mus musculus"]}}