{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336853/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336853"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"New taxonomy based on individual patient-reported response trajectories defines ulcerative colitis endotypes and reveals vascular inflammation as a mechanism for vedolizumab nonresponse.","description":"A major barrier to precision medicine for ulcerative colitis (UC) is the inability to predict and mechanistically explain treatment responses. Using daily patient-reported outcomes from a phase 3b comparative trial of 768 participants, we identified four distinct patient response trajectory groups for vedolizumab (anti-integrin) and adalimumab (antitumor necrosis factor) in UC. Validation in a second phase 3 trial of 591 participants linked vedolizumab trajectories to long-term disease complications. Bulk, single-cell, and spatial, transcriptomics and proteomics, identified vascular inflammation to be associated with vedolizumab nonresponse via SPP1+ monocytes and the angiopoetin-2 pathway. In a real-world cohort of 3,187 patients with UC, concomitant use of renin-angiotensin system inhibitors (modulators of vascular inflammation and angiopoietin-2 signaling) was associated with reduced long-term complications for vedolizumab but not anti-cytokine therapies. These findings define a response trajectory-based taxonomy, and endotype-specific outcome prediction, implicating vascular inflammation as a drug-specific and targetable resistance pathway for vedolizumab in UC.","dates":{"publication":"2026/09/15"},"accession":"GSE336853","cross_references":{"GSM":["GSM9843770","GSM9843771","GSM9843772","GSM9843765","GSM9843766","GSM9843767","GSM9843768","GSM9843769"],"GPL":["33484"],"GSE":["336853"],"taxon":["Homo sapiens"]}}