{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336897/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336897"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of peripheral kappa-opioid receptor agonists on murine T cells","description":"This study investigated the transcriptional responses of murine T cell subsets to treatment with novel peripherally restricted, perhydroquinoxaline-derived kappa opioid receptor (KOR) agonists. We sorted and polarized primary murine CD4+ and CD8+ T cells towards Th1, Th17, Treg and CD8+ T cells and stimulated them with novel KOR agonists or vehicle control (DMSO). RNA sequencing was performed to assess gene expression changes associated with KOR activation across distinct T cell subsets.","dates":{"publication":"2026/07/03"},"accession":"GSE336897","cross_references":{"GSM":["GSM9844264","GSM9844253","GSM9844265","GSM9844254","GSM9844266","GSM9844255","GSM9844245","GSM9844267","GSM9844256","GSM9844268","GSM9844246","GSM9844257","GSM9844258","GSM9844247","GSM9844248","GSM9844259","GSM9844249","GSM9844260","GSM9844261","GSM9844250","GSM9844251","GSM9844262","GSM9844263","GSM9844252"],"GPL":["34290"],"GSE":["336897"],"taxon":["Mus musculus"]}}