GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336897/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336897GEOGSEfalseEffect of peripheral kappa-opioid receptor agonists on murine T cellsThis study investigated the transcriptional responses of murine T cell subsets to treatment with novel peripherally restricted, perhydroquinoxaline-derived kappa opioid receptor (KOR) agonists. We sorted and polarized primary murine CD4+ and CD8+ T cells towards Th1, Th17, Treg and CD8+ T cells and stimulated them with novel KOR agonists or vehicle control (DMSO). RNA sequencing was performed to assess gene expression changes associated with KOR activation across distinct T cell subsets.2026/07/03GSE336897GSM9844264GSM9844253GSM9844265GSM9844254GSM9844266GSM9844255GSM9844245GSM9844267GSM9844256GSM9844268GSM9844246GSM9844257GSM9844258GSM9844247GSM9844248GSM9844259GSM9844249GSM9844260GSM9844261GSM9844250GSM9844251GSM9844262GSM9844263GSM984425234290336897Mus musculus