GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337023/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337023GEOGSEfalseGenomic and transcriptomic profiling of whole-genome-doubled triple-negative breast cancer cell populationsTo investigate whether the mechanism of whole-genome doubling (WGD) results in distinct genomic and transcriptomic phenotypes, we compared three routes to WGD against their respective parental aneuploid controls across two triple-negative breast cancer (TNBC) cell lines (HCC1806 and MDA-MB-231). WGD mechanisms included naturally occurring cell-cell fusion and two drug-induced cell-cycle error mechanisms: mitotic slippage (MS) and cytokinesis failure (CF). All populations were profiled in biological triplicate by TagSeq (3' tag-based RNA-seq) for transcriptomic analysis and low-pass whole-genome sequencing (WGS) for copy-number profiling.2026/07/05GSE337023GSM9846896GSM9846898GSM9846897GSM9846911GSM9846900GSM9846899GSM9846910GSM9846913GSM9846902GSM9846901GSM9846912GSM9846904GSM9846915GSM9846914GSM9846903GSM9846906GSM9846917GSM9846916GSM9846905GSM9846919GSM9846908GSM9846907GSM9846918GSM984690930173337023Homo sapiens