{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337046/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337046"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The distinct expression features between chronic phase and B-lymphoblastic crisis samples from patients with CML","description":"Chronic myeloid leukemia (CML) is a biphasic clonal hematopoietic stem cell disorder driven by the Philadelphia chromosome (Ph)-encoded BCR::ABL1 oncogene. The blast phase (BP) in CML progressed from indolent chronic phase (CP), usually has a dismal outcome. Single-cell RNA sequencing (scRNA-seq) have identified the pretreatment features linked to therapy resistance and disease progression. We performed the scRNA-seq on bone marrow cells derived from paired CML-CP and CML-BLBC samples, and found that CD24 displayed a striking upregulation in CML-BLBC samples when compared with both the CML-CP and Ph+ B-ALL samples, suggesting the potential as a target in the future therapy of patients with CML-BLBC. Therefore, we profiled the BM samples from patients with CML-CP (n = 16), CML-BLBC (n = 8), and de novo Ph+ B-ALL (n = 13) using bulk RNA sequencing to validate the upregulated expressio of CD24 in patients with CML-BLBC.","dates":{"publication":"2026/06/30"},"accession":"GSE337046","cross_references":{"GSM":["GSM9847389","GSM9847401","GSM9847388","GSM9847402","GSM9847400","GSM9847405","GSM9847406","GSM9847403","GSM9847404","GSM9847409","GSM9847407","GSM9847408","GSM9847381","GSM9847383","GSM9847382","GSM9847385","GSM9847384","GSM9847387","GSM9847386","GSM9847412","GSM9847399","GSM9847413","GSM9847410","GSM9847411","GSM9847416","GSM9847417","GSM9847414","GSM9847415","GSM9847390","GSM9847392","GSM9847391","GSM9847394","GSM9847393","GSM9847396","GSM9847395","GSM9847398","GSM9847397"],"GPL":["24676"],"GSE":["337046"],"taxon":["Homo sapiens"]}}