{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337330/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337330"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Housing Mice in Thermoneutrality Causes Tissue-specific Changes in Number, Identity, and Phase of Circadian-expressed mRNA Transcripts","description":"Mice housed at room temperature (RT, 25°C) experience chronic mild cold stress compared with those housed at thermoneutrality (TN, 30°C). We hypothesized that cold stress suppresses circadian transcript expression in peripheral tissues. RNA-seq of hearts, livers, and diaphragms collected every 4 hours over 48 hours in constant darkness identified mRNA transcripts exhibiting ≈24-hour rhythms (REGs). TN produced tissue-specific changes in REG number, identity, and phase without altering core circadian clock transcript levels. Cardiac REGs increased 4-fold, diaphragm REGs 1.5-fold, and hepatic REG identity shifted substantially. GO analysis revealed coordinated reorganization of rhythmic metabolic programs in the heart and liver. These data demonstrate that ambient housing temperature has tissue-specific effects on the number, identity, and temporal organization of rhythmically expressed transcripts in the heart, liver, and diaphragm.","dates":{"publication":"2026/09/24"},"accession":"GSE337330","cross_references":{"GSM":["GSM9853248","GSM9853249","GSM9853246","GSM9853247","GSM9853244","GSM9853245","GSM9853242","GSM9853243","GSM9853240","GSM9853241","GSM9853259","GSM9853257","GSM9853258","GSM9853255","GSM9853256","GSM9853253","GSM9853254","GSM9853251","GSM9853252","GSM9853250","GSM9853309","GSM9853307","GSM9853308","GSM9853305","GSM9853306","GSM9853303","GSM9853304","GSM9853301","GSM9853268","GSM9853269","GSM9853302","GSM9853266","GSM9853300","GSM9853267","GSM9853264","GSM9853265","GSM9853262","GSM9853263","GSM9853260","GSM9853261","GSM9853318","GSM9853319","GSM9853316","GSM9853317","GSM9853314","GSM9853315","GSM9853312","GSM9853279","GSM9853313","GSM9853277","GSM9853310","GSM9853278","GSM9853311","GSM9853275","GSM9853276","GSM9853273","GSM9853274","GSM9853271","GSM9853272","GSM9853270","GSM9853329","GSM9853208","GSM9853209","GSM9853206","GSM9853327","GSM9853207","GSM9853328","GSM9853204","GSM9853325","GSM9853326","GSM9853205","GSM9853323","GSM9853202","GSM9853203","GSM9853324","GSM9853200","GSM9853321","GSM9853288","GSM9853289","GSM9853201","GSM9853322","GSM9853286","GSM9853320","GSM9853287","GSM9853284","GSM9853285","GSM9853282","GSM9853283","GSM9853280","GSM9853281","GSM9853219","GSM9853217","GSM9853338","GSM9853218","GSM9853339","GSM9853215","GSM9853336","GSM9853337","GSM9853216","GSM9853334","GSM9853213","GSM9853214","GSM9853335","GSM9853211","GSM9853332","GSM9853299","GSM9853212","GSM9853333","GSM9853297","GSM9853330","GSM9853298","GSM9853210","GSM9853331","GSM9853295","GSM9853296","GSM9853293","GSM9853294","GSM9853291","GSM9853292","GSM9853290","GSM9853349","GSM9853228","GSM9853229","GSM9853226","GSM9853347","GSM9853348","GSM9853227","GSM9853224","GSM9853345","GSM9853346","GSM9853225","GSM9853343","GSM9853222","GSM9853223","GSM9853344","GSM9853220","GSM9853341","GSM9853221","GSM9853342","GSM9853340","GSM9853239","GSM9853237","GSM9853238","GSM9853235","GSM9853236","GSM9853233","GSM9853354","GSM9853234","GSM9853355","GSM9853231","GSM9853198","GSM9853352","GSM9853353","GSM9853232","GSM9853199","GSM9853350","GSM9853197","GSM9853230","GSM9853351"],"GPL":["34290"],"GSE":["337330"],"taxon":["Mus musculus"],"PMID":["[42146544]"]}}