{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337539/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337539"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"scRNAseq of LCMV-specific P14 cells: WT, P2RX7-KO and NKG7-KO","description":"We have used Parse Biosciences to generate single-cell RNAseq libraries from P14 CD8+ T cells (wild-type - WT, P2RX7-KO and NKG7-KO) collected from mice infected with either LCMV-Armstrong or LCMV-Clone 13 (days 0, 7 or 30 post-infection). The goal of this study was to determine the transcriptional alterations in memory or exhausted CD8+ T cells driven by the absence of either P2RX7 (a purinergic receptor that senses extracellular ATP) or NKG7 (a metabolic regulator that can downregulate mTORC1 and simultaneously induce cytotoxicity).","dates":{"publication":"2026/07/08"},"accession":"GSE337539","cross_references":{"GSM":["GSM9857601","GSM9857602","GSM9857603","GSM9857604","GSM9857605","GSM9857606","GSM9857607","GSM9857608"],"GPL":["34290"],"GSE":["337539"],"taxon":["Mus musculus"]}}