{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337812/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337812"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomics reveals D2-associated synaptic transcriptional attenuation in the chronically stressed dorsal striatum","description":"Chronic stress alters striatal functions involved in motivation, action selection, and behavioral adaptation, yet cell-type-associated transcriptional organization in the dorsal striatum remains unclear. We used RNAscope-guided GeoMx spatial transcriptomics to compare D1- and D2-enriched neuronal compartments within anatomically matched dorsal striatal regions after chronic restraint stress. Chronic restraint stress engaged both populations and produced comparable numbers of differentially expressed genes. Pathway-level analysis revealed partially overlapping transcriptional attenuation in D1 and D2 neurons, whereas D2 responses showed more coherent organization around receptor-trafficking and synaptic signaling programs. CRS-downregulated D2 genes further resolved into synapse-centered functional categories, including glutamatergic synapse, postsynaptic organization, and dendritic spine.","dates":{"publication":"2026/07/09"},"accession":"GSE337812","cross_references":{"GSM":["GSM9860915","GSM9860914","GSM9860913","GSM9860912","GSM9860919","GSM9860918","GSM9860917","GSM9860916","GSM9860900","GSM9860922","GSM9860921","GSM9860920","GSM9860909","GSM9860926","GSM9860904","GSM9860903","GSM9860925","GSM9860924","GSM9860902","GSM9860923","GSM9860901","GSM9860908","GSM9860929","GSM9860907","GSM9860906","GSM9860928","GSM9860927","GSM9860905","GSM9860896","GSM9860895","GSM9860894","GSM9860893","GSM9860911","GSM9860910","GSM9860899","GSM9860898","GSM9860897","GSM9860892"],"GPL":["24247"],"GSE":["337812"],"taxon":["Mus musculus"]}}