GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337812/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337812GEOGSEfalseSpatial transcriptomics reveals D2-associated synaptic transcriptional attenuation in the chronically stressed dorsal striatumChronic stress alters striatal functions involved in motivation, action selection, and behavioral adaptation, yet cell-type-associated transcriptional organization in the dorsal striatum remains unclear. We used RNAscope-guided GeoMx spatial transcriptomics to compare D1- and D2-enriched neuronal compartments within anatomically matched dorsal striatal regions after chronic restraint stress. Chronic restraint stress engaged both populations and produced comparable numbers of differentially expressed genes. Pathway-level analysis revealed partially overlapping transcriptional attenuation in D1 and D2 neurons, whereas D2 responses showed more coherent organization around receptor-trafficking and synaptic signaling programs. CRS-downregulated D2 genes further resolved into synapse-centered functional categories, including glutamatergic synapse, postsynaptic organization, and dendritic spine.2026/07/09GSE337812GSM9860915GSM9860914GSM9860913GSM9860912GSM9860919GSM9860918GSM9860917GSM9860916GSM9860900GSM9860922GSM9860921GSM9860920GSM9860909GSM9860926GSM9860904GSM9860903GSM9860925GSM9860924GSM9860902GSM9860923GSM9860901GSM9860908GSM9860929GSM9860907GSM9860906GSM9860928GSM9860927GSM9860905GSM9860896GSM9860895GSM9860894GSM9860893GSM9860911GSM9860910GSM9860899GSM9860898GSM9860897GSM986089224247337812Mus musculus