{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337880/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337880"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Comparative RNA-seq profiling of human HER2+ JIMT1-BR3 and JIMT1-BR3-LM4 breast cancer cells","description":"A human HER2-positive leptomeningeal colonization model, JIMT1-BR3-LM4, was established by intrathecal injection of the JIMT1-BR3 HER2+ cell line, which already formed parenchymal brain metastases and occasional leptomeningeal metastases. In this study, bulk RNA sequencing was performed to define transcriptomic differences between parental JIMT1-BR3 cells and the leptomeningeal-tropic derivative JIMT1-BR3-LM4. These data provide a resource for identifying gene expression changes associated with HER2-positive breast cancer leptomeningeal colonization.","dates":{"publication":"2026/09/15"},"accession":"GSE337880","cross_references":{"GSM":["GSM9862263","GSM9862262","GSM9862261","GSM9862260","GSM9862265","GSM9862264"],"GPL":["30173"],"GSE":["337880"],"taxon":["Homo sapiens"],"PMID":["[42637135]"]}}