GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337880/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337880GEOGSEfalseComparative RNA-seq profiling of human HER2+ JIMT1-BR3 and JIMT1-BR3-LM4 breast cancer cellsA human HER2-positive leptomeningeal colonization model, JIMT1-BR3-LM4, was established by intrathecal injection of the JIMT1-BR3 HER2+ cell line, which already formed parenchymal brain metastases and occasional leptomeningeal metastases. In this study, bulk RNA sequencing was performed to define transcriptomic differences between parental JIMT1-BR3 cells and the leptomeningeal-tropic derivative JIMT1-BR3-LM4. These data provide a resource for identifying gene expression changes associated with HER2-positive breast cancer leptomeningeal colonization.2026/09/15GSE337880GSM9862263GSM9862262GSM9862261GSM9862260GSM9862265GSM986226430173337880Homo sapiens[42637135]