{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337898/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337898"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ATAC-seq profiling of lineage-traced exhausted and memory-like CD8+ T cell subsets during tumor progression","description":"To investigate the epigenetic landscape of tumor-reactive exhausted CD8+ T cells, ATAC-seq was performed on fluorescence-activated cell sorted CD8+ T cell subsets isolated from Lag3^iCreERT2^ Rosa26^LSL-tdTomato^ mice bearing B16-F10 melanoma tumors. Chromatin accessibility profiles were generated for lineage-traced LAG3^+tdTomato^+, LAG3^-tdTomato^+, and corresponding control CD8+ T cell populations isolated from tumors and draining lymphoid tissues. These data were used to characterize chromatin accessibility changes associated with exhausted, progenitor-like, and memory-like CD8+ T cell states and to define epigenetic relationships among lineage-traced T cell populations.","dates":{"publication":"2026/07/24"},"accession":"GSE337898","cross_references":{"GSM":["GSM9862458","GSM9862447","GSM9862446","GSM9862457","GSM9862445","GSM9862456","GSM9862455","GSM9862444","GSM9862449","GSM9862459","GSM9862448","GSM9862450","GSM9862461","GSM9862460","GSM9862443","GSM9862465","GSM9862454","GSM9862453","GSM9862464","GSM9862442","GSM9862452","GSM9862463","GSM9862462","GSM9862451"],"GPL":["24247"],"GSE":["337898"],"taxon":["Mus musculus"],"PMID":["[42611047]"]}}