GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337898/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337898GEOGSEfalseATAC-seq profiling of lineage-traced exhausted and memory-like CD8+ T cell subsets during tumor progressionTo investigate the epigenetic landscape of tumor-reactive exhausted CD8+ T cells, ATAC-seq was performed on fluorescence-activated cell sorted CD8+ T cell subsets isolated from Lag3^iCreERT2^ Rosa26^LSL-tdTomato^ mice bearing B16-F10 melanoma tumors. Chromatin accessibility profiles were generated for lineage-traced LAG3^+tdTomato^+, LAG3^-tdTomato^+, and corresponding control CD8+ T cell populations isolated from tumors and draining lymphoid tissues. These data were used to characterize chromatin accessibility changes associated with exhausted, progenitor-like, and memory-like CD8+ T cell states and to define epigenetic relationships among lineage-traced T cell populations.2026/07/24GSE337898GSM9862458GSM9862447GSM9862446GSM9862457GSM9862445GSM9862456GSM9862455GSM9862444GSM9862449GSM9862459GSM9862448GSM9862450GSM9862461GSM9862460GSM9862443GSM9862465GSM9862454GSM9862453GSM9862442GSM9862464GSM9862452GSM9862463GSM9862462GSM986245124247337898Mus musculus[42611047]