{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337899/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by genome tiling array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337899"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Methylomic Analysis of Nasal Brushings Poorly Discriminates Subgroups in Pediatric Acute Respiratory Distress Syndrome","description":"Pediatric acute respiratory distress syndrome (PARDS) is biologically heterogeneous. To determine whether the nasal epithelial methylome identifies subgroups of PARDS, we profiled genome-wide DNA methylation in nasal brushings from 21 children with PARDS and 3 pediatric ICU controls using the Infinium MethylationEPIC v2.0 array. After estimating and adjusting for cell-type composition, we performed unsupervised clustering and cell-type-specific differential methylation analysis. Cellular composition explained the majority of variation in the unadjusted methylome, and composition-adjusted clustering yielded only weak subgroup structure. These data indicate that, at this sample size, the nasal methylome poorly discriminates PARDS subgroups.","dates":{"publication":"2026/07/07"},"accession":"GSE337899","cross_references":{"GSM":["GSM9862490","GSM9862502","GSM9862501","GSM9862500","GSM9862489","GSM9862499","GSM9862488","GSM9862503","GSM9862494","GSM9862483","GSM9862482","GSM9862493","GSM9862492","GSM9862481","GSM9862491","GSM9862480","GSM9862487","GSM9862498","GSM9862497","GSM9862486","GSM9862496","GSM9862485","GSM9862484","GSM9862495"],"GPL":["33022"],"GSE":["337899"],"taxon":["Homo sapiens"]}}