GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337902/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337902GEOGSEfalseTumor-specific memory-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cellsChronic antigen stimulation induces CD8+ T cell exhaustion (TEX) in tumors. To investigate the developmental fate and heterogeneity of exhausted T cells, we generated an inducible Lag3^iCreERT2 Rosa26^LSL-tdTomato lineage-tracing mouse model and profiled lineage-traced CD8+ T cells isolated from tumors and peripheral lymphoid tissues at multiple time points following B16-F10 melanoma challenge. Single-cell RNA sequencing, paired TCR sequencing, and ATAC-seq were performed to characterize transcriptional, clonal, and epigenetic states of LAG3^+tdTomato^+, LAG3^-tdTomato^+, and corresponding control CD8+ T cell populations. These datasets provide a resource for studying the differentiation trajectories, clonal relationships, and chromatin remodeling underlying exhausted and memory-like tumor-reactive CD8+ T cells.2026/07/24GSE337902GSM9862529GSM9862535GSM9862534GSM9862544GSM9862533GSM9862532GSM9862543GSM9862528GSM9862539GSM9862527GSM9862538GSM9862537GSM9862536GSM9862531GSM9862542GSM9862530GSM9862541GSM986254024247337902Mus musculus[42611047]