{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337937/suppl/GSE337937_gene_count.xlsx"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337937/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337937"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RASA3 inhibits Tc1 differentiation and attenuates anti-bacteria immunity by restricting the HCK kinase","description":"Type I immunity is defined by IFN-γ secretion, with Tc1 cells as a key subset, yet their intrinsic negative regulators remain unclear. We identified RASA3 as a novel negative regulator of Tc1 cells. T cell-specific deletion of RASA3 enhanced Tc1 differentiation and antibacterial immunity. We further revealed the RASA3–HCK–STAT4 axis in the regulatoin of Tc1 cell generation.","dates":{"publication":"2026/07/09"},"accession":"GSE337937","cross_references":{"GSM":["GSM9863225","GSM9863226","GSM9863227","GSM9863222","GSM9863223","GSM9863224"],"GPL":["24247"],"GSE":["337937"],"taxon":["Mus musculus"]}}