{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338025/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing"," Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338025"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Multiome analysis of PDxOs (HCI-003, HCI-005, HCI-011) treated with a CDK4/6 inhibitor for 3 weeks","description":"This study uses single-nucleus multiome profiling, as well as bulk methylation profiling, to characterize the transcriptional, chromatin accessibility, and DNA methylation changes after 3 weeks of CDK4/6 inhibitor treatment in organoids grown from patient-derived xenograft tumors (PDxOs) generated from 3 patients: HCI-003, HCI-005, and HCI-011.","dates":{"publication":"2026/07/13"},"accession":"GSE338025","cross_references":{"GSM":["GSM9864769","GSM9864787","GSM9864765","GSM9864766","GSM9864788","GSM9864789","GSM9864767","GSM9864768","GSM9864783","GSM9864784","GSM9864763","GSM9864785","GSM9864786","GSM9864764","GSM9864780","GSM9864781","GSM9864782","GSM9864798","GSM9864776","GSM9864777","GSM9864778","GSM9864779","GSM9864772","GSM9864794","GSM9864795","GSM9864773","GSM9864796","GSM9864774","GSM9864775","GSM9864797","GSM9864790","GSM9864791","GSM9864792","GSM9864770","GSM9864793","GSM9864771"],"GPL":["34281"],"GSE":["338025"],"taxon":["Homo sapiens"]}}