GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338025/primaryOK200TranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencing OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338025GEOGSEfalseMultiome analysis of PDxOs (HCI-003, HCI-005, HCI-011) treated with a CDK4/6 inhibitor for 3 weeksThis study uses single-nucleus multiome profiling, as well as bulk methylation profiling, to characterize the transcriptional, chromatin accessibility, and DNA methylation changes after 3 weeks of CDK4/6 inhibitor treatment in organoids grown from patient-derived xenograft tumors (PDxOs) generated from 3 patients: HCI-003, HCI-005, and HCI-011.2026/07/13GSE338025GSM9864769GSM9864787GSM9864765GSM9864766GSM9864788GSM9864789GSM9864767GSM9864768GSM9864783GSM9864784GSM9864763GSM9864785GSM9864786GSM9864764GSM9864780GSM9864781GSM9864782GSM9864798GSM9864776GSM9864777GSM9864778GSM9864779GSM9864772GSM9864794GSM9864795GSM9864773GSM9864796GSM9864774GSM9864775GSM9864797GSM9864790GSM9864791GSM9864792GSM9864770GSM9864793GSM986477134281338025Homo sapiens