GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338053/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338053GEOGSEfalse3-Hydroxyanthranilic acid suppresses colorectal cancer growth and enhances 5-fluorouracil sensitivity via the YY1–p53 and YY1–DKK4 axes [RNA-Seq 3HAA_5FU_HCT116]In spite of its reported tumor-growth-inhibition activity, the role of the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) in colorectal cancer (CRC) remains unclear. Here, 3-HAA exhibited depleted levels in CRC tissues, and its exogenous administration effectively suppressed the proliferation of multiple CRC cell lines. Through its binding to the Yin Yang 1 (YY1) transcription factor, it disrupted the YY1–p53 interaction, preserved p53 stability, and induced cell cycle arrest. Notably, in vitro, 3-HAA reduced chemoresistance to the common CRC-chemotherapy drug 5-fluorouracil (5-FU) via the YY1–DKK4 axis. Consistently, in vivo, combined 3-HAA–5-FU treatment effectively inhibited CRC progression, highlighting the potential of 3-HAA for CRC therapy.2026/09/11GSE338053GSM9865380GSM9865378GSM9865377GSM9865379GSM9865374GSM9865373GSM9865376GSM986537534284338053Homo sapiens