{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338068/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338068"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide RRBS methylation profiling identifies NLRP7 promoter hypermethylation associated with disease severity in epidermolysis bullosa simplex","description":"Reduced representation bisulfite sequencing (RRBS) was performed to investigate DNA methylation profiles in patients with epidermolysis bullosa (EB) exhibiting variable disease severity. Differential methylation analysis identified a differentially methylated region within the NLRP7 promoter and first exon. The dataset provides genome-wide DNA methylation profiles generated from peripheral blood leukocyte DNA and is intended to facilitate studies of epigenetic mechanisms associated with EBS disease severity.","dates":{"publication":"2026/07/10"},"accession":"GSE338068","cross_references":{"GSM":["GSM9865907","GSM9865906","GSM9865908","GSM9865877","GSM9865899","GSM9865898","GSM9865876","GSM9865879","GSM9865878","GSM9865895","GSM9865873","GSM9865894","GSM9865872","GSM9865897","GSM9865875","GSM9865874","GSM9865896","GSM9865891","GSM9865890","GSM9865893","GSM9865871","GSM9865892","GSM9865903","GSM9865902","GSM9865905","GSM9865904","GSM9865888","GSM9865887","GSM9865901","GSM9865900","GSM9865889","GSM9865884","GSM9865883","GSM9865886","GSM9865885","GSM9865880","GSM9865882","GSM9865881"],"GPL":["18460"],"GSE":["338068"],"taxon":["Homo sapiens"]}}