GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338068/primaryOK200Methylation profilingHomo sapiensMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338068GEOGSEfalseGenome-wide RRBS methylation profiling identifies NLRP7 promoter hypermethylation associated with disease severity in epidermolysis bullosa simplexReduced representation bisulfite sequencing (RRBS) was performed to investigate DNA methylation profiles in patients with epidermolysis bullosa (EB) exhibiting variable disease severity. Differential methylation analysis identified a differentially methylated region within the NLRP7 promoter and first exon. The dataset provides genome-wide DNA methylation profiles generated from peripheral blood leukocyte DNA and is intended to facilitate studies of epigenetic mechanisms associated with EBS disease severity.2026/07/10GSE338068GSM9865907GSM9865906GSM9865908GSM9865877GSM9865899GSM9865898GSM9865876GSM9865879GSM9865878GSM9865895GSM9865873GSM9865894GSM9865872GSM9865897GSM9865875GSM9865874GSM9865896GSM9865891GSM9865890GSM9865893GSM9865871GSM9865892GSM9865903GSM9865902GSM9865905GSM9865904GSM9865888GSM9865887GSM9865901GSM9865900GSM9865889GSM9865884GSM9865883GSM9865886GSM9865885GSM9865880GSM9865882GSM986588118460338068Homo sapiens