{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338199/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338199"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Cannabidiol reverses neuroimmune priming in aged Gulf War Illness mice","description":"Gulf War Illness (GWI) affects up to one-third of 1990–1991 Gulf War veterans and is associated with chronic low-grade neuroinflammation, yet its cellular substrates remain unclear and targeted pharmacological therapies are still limited. By using bulk RNA-seq analyses of whole-brain in an established GWI mouse model, we uncovered a multi-lineage primed neuroimmune signature in aged GWI mice. Systemic lipopolysaccharide (LPS) elicited an amplified pro-inflammatory response in the brains of GWI mice compared to age-matched controls. Chronic cannabidiol (CBD) attenuated neuroimmune priming at baseline, and suppressed the parenchymal hyper-response, defining a therapeutic axis amenable to pharmacological intervention.","dates":{"publication":"2026/07/14"},"accession":"GSE338199","cross_references":{"GSM":["GSM9869156","GSM9869145","GSM9869144","GSM9869155","GSM9869154","GSM9869165","GSM9869164","GSM9869153","GSM9869152","GSM9869163","GSM9869151","GSM9869162","GSM9869161","GSM9869150","GSM9869160","GSM9869149","GSM9869159","GSM9869148","GSM9869158","GSM9869147","GSM9869157","GSM9869146"],"GPL":["24247"],"GSE":["338199"],"taxon":["Mus musculus"]}}